26 August 2024
: Case report 
Early Detection of Subclinical Corneal Abnormalities: Biophotonic Imaging Reveals Hyporeflective Bleb-Like Structures in Asymptomatic Eyes
Unknown etiology, Challenging differential diagnosis
Katharina Anna Sterenczak12ADEF, Karsten Sperlich
13BCDE, Sebastian Bohn13BCEF, Friederike Schaub1DEF, Oliver Stachs13ADEFG*
DOI: 10.12659/AJCR.944321
Am J Case Rep 2024; 25:e944321
Figure 2. (A, B) Correlative imaging using high-resolution optical coherence tomography (OCT) and large-area confocal laser scanning microscopy (CLSM). Non-invasive biophotonic imaging of asymptomatic corneas ((A) – OD, (B) – OS) in a 57-year-old male patient: in vivo OCT and large-area CLSM analysis. Section a is the corneal epithelium, section b is the sub-basal nerve plexus, and section c is the anterior stroma. Atypical hyporeflective bleb-like structures were observed in the corneal epithelium of both eyes (section a) and sub-basal nerve plexus (section b), milder in the right eye, but not in the stroma (section c).