01 September 2024
: Case report
A Challenging Diagnosis of HHV-8-Associated Diffuse Large B-Cell Lymphoma, Not Otherwise Specified, in a Young Man with Newly-Diagnosed HIV
Unusual clinical course, Challenging differential diagnosis, Rare disease
Ami Dave1BDEF, Michael Schwartz2EF, Jeremy Van3EF, Laura Owczarzak2E*, Ira Miller4DE, Shivi Jain5DEFDOI: 10.12659/AJCR.945162
Am J Case Rep 2024; 25:e945162
Figure 1. Blood and marrow showing HHV8 infection with a background of reactive plasmacytosis. (A) Plasmacytoid cells with activated/immature features in the blood. (B) Increased reactive-appearing plasma cells (black arrows) and dysplastic normoblast (red arrow) in the aspirate smear (Wright-Giemsa stain). (C) Hypercellular marrow biopsy section (H&E) with increased plasma cells and megakaryocyte atypia. (D) CD138 immunostain of the biopsy showing increased plasma cells. (E) Kappa and (F) Lambda in situ hybridization stains of the marrow biopsy with a normal ratio of plasma cells staining, indicating reactive plasmacytosis. (G) Scattered HHV8-positive cells in the marrow biopsy.