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16 December 2024 : Case report  Japan

Perihilar Cholangiocarcinoma Originating in Peribiliary Glands: Insights from a Case without Precancerous Lesions

Unusual clinical course, Mistake in diagnosis

Yukihiro Shirota ORCID logo ABCDEF 1*, Yoshimichi Ueda ABCDEF 2, Yasuni Nakanuma ADEF 3, Yuichi Yoshie BDE 4, Yasuhito Takeda BDE 1, Yuji Hodo ORCID logo BDE 1, Tokio Wakabayashi BDE 1

DOI: 10.12659/AJCR.945519

Am J Case Rep 2024; 25:e945519

Figure 6. Autopsy bile duct findings. The common bile duct (A, yellow arrow head) shows an irregularly thickened wall and partially severely constricted lumen, but with a smooth surface. Around the common hepatic duct (B, yellow arrow head) and the duodenal bulb (B, yellow arrow) severe adhesion is shown. The hematoxylin and eosin-stained specimens in the low-power fields show periductal fibrous thickening continuously at the bifurcation of the right posterior or anterior sectoral duct (C, yellow arrow: it was difficult to distinguish between the right posterior and anterior sectoral ducts on liver excisions) from the left hepatic duct (C, yellow arrow head), at the upper common bile duct (D), and at the lower common bile duct (E). The specimen in the mid-power field shows well-differentiated adenocarcinoma with desmoplastic stroma in a periductal infiltrating pattern (F).

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923