A Rare Case of Metastatic Adrenocorticotrophic Hormone – Secreting Pancreatic Neuroendocrine Tumor Causing Ectopic Cushing Syndrome in a 46-Year-Old Woman

Jessica Y. Huang; Nikitha A. Cherayil; Paul Boyd; Maher Ali; Shazia Samanani

doi:10.12659/AJCR.945653

03 April 2025 : Case report USA

A Rare Case of Metastatic Adrenocorticotrophic Hormone – Secreting Pancreatic Neuroendocrine Tumor Causing Ectopic Cushing Syndrome in a 46-Year-Old Woman

Challenging differential diagnosis, Rare disease

Jessica Y. Huang^1ABCDEF, Nikitha A. Cherayil

^2CDEF, Paul Boyd

^1ACE, Maher Ali^3BCD, Shazia Samanani^1ABCDEF*

DOI: 10.12659/AJCR.945653

Am J Case Rep 2025; 26:e945653

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Figure 7. (A) Hematoxylin and eosin at 60× magnification: tumor cells exhibit large vesicular nuclei with prominent nucleoli. (B) Chromogranin at 20× magnification: diffuse and strong positive staining is observed in tumor cells, confirming neuroendocrine differentiation. (C) Synaptophysin at 20× magnification: tumor cells are strongly positive for synaptophysin. (D) Ki-67 at 20× magnification: the Ki-67 labeling index is at least 60%, indicating a high proliferative rate.

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A Rare Case of Metastatic Adrenocorticotrophic Hormone – Secreting Pancreatic Neuroendocrine Tumor Causing Ectopic Cushing Syndrome in a 46-Year-Old Woman

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