31 May 2025
: Case report 
Granulomatosis with Polyangiitis Presenting as Pancreatic Pseudotumor and Peripancreatic Lymphadenitis: Diagnostic Challenges and Review of 55 Cases
Mistake in diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents, Rare disease, Educational Purpose (only if useful for a systematic review or synthesis)
Camille Beniada ABCEF 1, Yann Coattrenec AE 1, Sahar Mack
ADEF 2, Alexis Ricoeur CD 3, Volkan Adsay CD 4,5, Giacomo Puppa DE 6, Jörg D. Seebach ACDEF 1*
DOI: 10.12659/AJCR.945741
Am J Case Rep 2025; 26:e945741
Figure 2 (A) Macroscopy of the pancreatic resection showing a 6.5×4.2×3.5 cm mass that was encapsulated, firm, heterogeneous, whitish-to-yellowish, with intermingled adipose tissue, no calcifications, no dilatation of the pancreatic ducts, and no associated cystic lesions; (B–D) histology: (B) low magnification of the granulomatous fibro-inflammatory and necrotic process; (C) higher magnification showing several multi-nucleated giant cells; (D) higher magnification of the blood vessel contained in the box of Figure 2B showing infiltration of the vessel walls by lymphoplasmacytic cells; (E) necrotizing vasculitis with vessel wall infiltration (higher magnification 12×), arrow – inflammatory lymphocytic infiltrate; star – necrosis.