13 February 2025
: Case report 
A 37-Year-Old Man with Multifocal Bilateral Malignant Testicular Large-Cell Calcifying Sertoli Cell Tumors Presenting as Painless Testicular Masses
Unusual clinical course, Challenging differential diagnosis, Rare disease
Lukas Dohmen ABDEF 1*, Mélissa Pani ADEF 2, Pierre Marchettini EF 1, François Devos AE 2DOI: 10.12659/AJCR.945910
Am J Case Rep 2025; 26:e945910
Figure 2. Photomicrographs of the diagnostic histopathology from a testicular mass in a 37-year-old man with multifocal, bilateral, malignant, large-cell calcifying Sertoli cell tumors (LCCSCTs). (A, B) Histological representation of testicular sections with disorganized tissue architecture, containing laminated Psammomatous mulberry-like calcifications (purple, white delineation, A, B) with inflammatory infiltration (black arrows, A, B), and replacement of the normal testicular tissue with large epithelioid cells including eosinophilic cytoplasm and prominent nucleoli (white arrows, B) with minimal cytological atypia. Hematoxylin and eosin (H&E). Magnification 20× (A) and 40× (B).