Figure 2. Representative photos of kidney biopsy. Panel A shows small fibrocellular crescents in the glomeruli (arrow). Proximal tubules show evidence of loss of the brush border, with dilation of the tubules and vascular wall intimal fibrosis (PAS, magnification: 100×). Panel B shows a representative glomerulus with a large cellular-fibro crescent and segmental necrosis (arrow, PASM, magnification: 400×). Panel C depicts electron-dense immune complex-type deposits in the subepithelial layer and inside the glomerular basement membrane (GBM, arrow), which is diagnostic for membranous glomerulopathy. Panel D demonstrates immunofluorescence IgG staining showing 3+ positivity linear and granular along the capillary loop (magnification: 1000×), indicating anti-GBM disease combined with membranous glomerulopathy. Panel E shows immunofluorescence staining demonstrating positivity of 3+ intensity for anti-PLA2R antibody expression (magnification: 400×). PAS – periodic acid Schiff staining; PASM – periodic acid silver methenamine staining; GBM – glomerular basement membrane; IgG – immunoglobin G; PLA2R – phospholipase A2 receptor.