23 February 2025
: Case report 
Rare Lacrimal Gland Melanoma: A Case Report and Treatment Insights
Challenging differential diagnosis, Unusual setting of medical care, Rare disease
Reinhard Told
ABCDEF 1*, Ana-Iris Schiefer BCDEF 2, Christoph Hoeller BCDEF 3, Adrian Reumueller ABCEF 1, Judith Kreminger ABCDEF 1, Roman Dunavoelgyi ABCDEF 1
DOI: 10.12659/AJCR.946361
Am J Case Rep 2025; 26:e946361
Figure 2. (A, B) Histopathology showing a destructive diffuse infiltration of the lacrimal gland (remnants marked with asterix) with epithelioid appearing tumor cells at low (A: 40×) and higher (B: 200×) magnification. Immunohistochemical work-up showed positivity for antibodies against HMB45 (C: 200×), S100 (D: 200×), Melan-A (E: 200×), and SOX10 (F: 200×). Secondary excision specimen showing a circumscribed subcutaneous tumor (asterix, G: 40× magnification) with more polymorphic pigmented tumor cells (asterix; H: 200× magnification). (I, J) Lung parenchyma with circumscribed metastatic tumor (I: 40×) composed of epithelioid appearing tumor cells (J: 200×).