Imatinib-Induced Clinical Response in ETV6::ACSL6 Myeloid Neoplasm with Eosinophilic Pneumonitis: A Case Report

Fieke W. Hoff; Sharon Germans; Olga K. Weinberg; Robert H. Collins Jr.; Rolando García; Weina Chen; Miguel D. Cantu; Mingyi Chen; Prasad Koduru; Jeffrey SoRelle; Yazan F. Madanat; Stephen S. Chung

doi:10.12659/AJCR.946517

09 April 2025 : Case report USA

Imatinib-Induced Clinical Response in ETV6::ACSL6 Myeloid Neoplasm with Eosinophilic Pneumonitis: A Case Report

Unusual or unexpected effect of treatment

Fieke W. Hoff^12ADEF*, Sharon Germans^3BD, Olga K. Weinberg^3BD, Robert H. Collins Jr.^12BD, Rolando García

^3BD, Weina Chen^3BD, Miguel D. Cantu

^3BD, Mingyi Chen

^3BD, Prasad Koduru

^3BD, Jeffrey SoRelle^3BD, Yazan F. Madanat^12ADE, Stephen S. Chung^124ADEG

DOI: 10.12659/AJCR.946517

Am J Case Rep 2025; 26:e946517

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Figure 1. Molecular characteristics of the present case. (A) G-banded karyogram demonstrating the t(5;12)(q31;p13) abnormality that was identified in 5 out of 6 cells examined. (B) Diagram of exons from ETV6 (exon 1) and ACSL6 (exons 2–21) highlighted that resulted in an out of frame fusion product with consequent frameshift and premature truncation. (C) RNA-sequencing of the tumor with colored lines in the Integrated Genome Viewer indicating a mapping pair in an alternative chromosome.

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Imatinib-Induced Clinical Response in ETV6::ACSL6 Myeloid Neoplasm with Eosinophilic Pneumonitis: A Case Report

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