15 March 2025
: Case report 
Incidental High-Grade Sellar Solitary Fibrous Tumor Mimicking Non-Functioning Pituitary Adenoma: A Case Report and Literature Review
Challenging differential diagnosis, Rare disease, Educational Purpose (only if useful for a systematic review or synthesis)
Michele Persico
ABCDEF 1*, Brent D. Weinberg BDE 2, Stewart G. Neill BDE 3, Hui-Kuo Shu E 4, Jim Zhong EG 4
DOI: 10.12659/AJCR.946592
Am J Case Rep 2025; 26:e946592
Figure 2. Pathological analysis of sellar mass specimen. (A) Hematoxylin and eosin (H&E) stain demonstrates histological findings of solitary fibrous tumor with markedly cellular mesenchymal neoplasm exhibiting morphology characteristic of a solitary fibrous tumor, with haphazardly arranged spindled to epithelioid cells (*) set in a variably collagenized background (**) aside dilated, tortuous vasculature (black triangle) and (B) high mitotic index (white arrow), consistent with a high-grade tumor. (C) Immunohistochemical staining for Signal Transducer and Activator Of Transcription 6 (STAT6) reveals strong nuclear immunoreactivity, a surrogate marker for the NFGI-A Binding Protein 2 (NAB2)-STAT6 fusion that is a hallmark of these tumors.