Diagnostic and Therapeutic Challenges in an Acute Variegate Porphyric Crisis Complicated by Anuric Renal Failure and Multiorgan Dysfunction: A Case Report

Peter B. Conroy; Sue Davel; Jacques A.J. Malherbe; Simon J. Carrivick; Edward N. Briggs

doi:10.12659/AJCR.946969

26 April 2025 : Case report Australia

Diagnostic and Therapeutic Challenges in an Acute Variegate Porphyric Crisis Complicated by Anuric Renal Failure and Multiorgan Dysfunction: A Case Report

Challenging differential diagnosis, Rare disease

Peter B. Conroy^{ABCDEF 1}, Sue Davel^{BCDEF 2}, Jacques A.J. Malherbe

^{BCDEF 3,4}, Simon J. Carrivick^{BCDEF 5}, Edward N. Briggs^{BCDEF 1*}

DOI: 10.12659/AJCR.946969

Am J Case Rep 2025; 26:e946969

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Figure 1. (A) Markedly xanthochromic cerebrospinal fluid obtained from the patient, suggestive of neurovisceral involvement by a variegate porphyria (VP) crisis. (B) Yellow-orange discoloration of the post-continuous renal replacement therapy (CRRT) dialysate effluent obtained from this patient.

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Diagnostic and Therapeutic Challenges in an Acute Variegate Porphyric Crisis Complicated by Anuric Renal Failure and Multiorgan Dysfunction: A Case Report

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