18 May 2025
: Case report 
Multiple Succinate Dehydrogenase-Deficient Gastrointestinal Stromal Tumors of the Stomach: A Case Report
Challenging differential diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents, Rare coexistence of disease or pathology
Xinxi Yang EF 1,2, Peng Yang B 3, Pengsen Guo C 1, Pan Nie D 1, Yuanyuan Chen B 3, Yanjun Liu A 1,2, Yingxin Wu AG 1*DOI: 10.12659/AJCR.947545
Am J Case Rep 2025; 26:e947545
Figure 4 Pathological images. (A, B) H&E stain ×100 magnification. The tumor tissue exhibits a diffuse distribution with tightly packed cells, occasionally arranged in sheet-like or fascicular patterns. The tumor margins are relatively well-defined, with some areas showing fibrous stromal separation and sparse vascular distribution. (C, D) H&E stain ×400 magnification. The tumor cells are round-to-oval, with mildly eosinophilic cytoplasm. The nuclei are large, with distinct nuclear membranes and visible nucleoli. Nuclear atypia is evident, with irregular chromatin distribution and occasional hyperchromatic nuclei.