Figure 3 Histopathological features of adrenal cortical adenoma with focal medullary hyperplasia. (A–F) Hematoxylin and eosin staining of adrenal tumor tissue sections demonstrates a clear zonal distinction between oncocytic and lipid-rich clear cells. (A, C, E) Low (100×), intermediate (200×), and high magnification (400×) views showing oncocytic cells with eosinophilic, granular cytoplasm, and sparse lipid droplets (black arrows). These cells are arranged in solid nests and trabeculae. (B, D, F) Corresponding magnifications highlighting lipid-rich clear cells (black arrows), characterized by vacuolated, optically clear cytoplasm and peripherally displaced nuclei. Notably, focal adrenal medullary hyperplasia is observed interspersed among cortical elements, indicating mixed histological features.