Figure 2 Virus-induced SIRS leads to MODS. After infection with the novel Bunyavirus, the virus exerts a direct and damaging effect on local tissues, which can subsequently induce a systemic inflammatory response syndrome (SIRS). If the condition progresses without appropriate intervention, it can ultimately lead to a severe and life-threatening scenario characterized by multiple organ dysfunction syndrome (MODS). This catastrophic progression may manifest as acute respiratory distress syndrome (ARDS), acute lung injury (ALI), acute kidney injury (AKI), acute pancreatic damage (AP), and the overarching complication of multiple organ failure (MOF). At this critical stage, the key points of treatment focus on several essential objectives: suppressing the inflammatory response to mitigate further tissue damage, correcting hypoxemia to ensure adequate oxygenation of vital organs, stabilizing hemodynamics to maintain proper blood circulation, and protecting and restoring the function of other affected organs to enhance the patient’s chances of recovery and survival.