Figure 4 The staging of inflammatory storm encephalitis/encephalopathy, its immune inflammatory phase, and the key points of immune regulation treatment in each stage. Storm encephalitis/encephalopathy can be divided into 3 stages: fever stage, encephalitis stage, and MODS stage. The fever period was generally within 1 week, and after 5–7 days, some patients may experience it at around 2–10 weeks, which is the encephalitis period. Once the condition gets out of control, serious complications can occur. During the immune inflammation phase, immune regulation therapy has several stages. In the early stage, it was in a state of high inflammation, requiring anti-inflammatory therapy. In the later stage, it was a problem of secondary infection caused by immune suppression, and it seemed more important to enhance immunity during this period. In the mid-term, it was a mixed process of SIRS and CARS, known as mixed antagonistic response syndrome (MARS), which requires both anti-inflammatory and immune enhancement.