24 November 2025
: Case report 
Hypophysitis Induced by Tislelizumab: A Case Report of Somnolence and Delirium with Elevated Eosinophils
Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents, Adverse events of drug therapy, Educational Purpose (only if useful for a systematic review or synthesis)
Fenglin Hu ABCDEFG 1, Ni Lou BCF 2, Guolin Wu EF 1*DOI: 10.12659/AJCR.948143
Am J Case Rep 2025; 26:e948143
Figure 1 The pathological and immunohistochemical (ICH) findings from the lymph node biopsy specimen in this patient. (A) Hematoxylin and eosin staining revealed a mixture of epithelial and mesenchymal components within the tumor tissue, arranged in an intermingled or well-demarcated pattern. (B) Cytokeratin 7 ICH staining in the tumor tissue was positive. (C) Vimentin ICH staining in the tumor tissue was positive. (D) Ki-67 ICH staining in the tumor tissue showed partial positivity. (E) Cyclin-dependent kinase inhibitor 2A ICH staining in the tumor tissue was positive. (F) ICH staining for estrogen receptor revealed focal positivity in the tumor tissue. (G) Progesterone receptor ICH staining in the tumor tissue was negative.