18 October 2025
: Case report 
Exploring Anti-TNF Therapy in Relapsing Polychondritis with Co-Existing Ulcerative Colitis: A Case Report and Literature Review
Unusual setting of medical care, Educational Purpose (only if useful for a systematic review or synthesis), Rare coexistence of disease or pathology
Safi G. Alqatari ABDEF 1, Abdullah A. Al-Abdulwahab ABDEF 1, Ibrahim A. Alhafid ABDEF 1, Abrar J. Alwaheed ABC 1, Methal I. AlBayat ABDF 2, Moath T. Alkhouzaie ABDEF 1, Mohammed A. Alhussain ABDEF 1, Reem S. AlSulaiman AEF 1*, Amal S. AlSulaiman ABCEF 1, Ahmed M. Abu Quren ABEF 3DOI: 10.12659/AJCR.948279
Am J Case Rep 2025; 26:e948279
Figure 2 Colonoscopy and histopathology findings of the patient presented in the case report. (A) Colonoscopic image demonstrating diffuse mucosal erythema, edema, friability, and loss of the normal vascular pattern. (B) Colonoscopic image revealing severe diffuse mucosal inflammation, erosions, cryptitis, and crypt abscesses. (C) Crypt architectural distortion, namely irregular spacing and size of crypts and crypt shortening. Inflammatory expansion of the lamina propria with basal lymphoplasmacytosis is also present. (D) Active colitis in the form of crypt abscess is seen. The lamina propria is expanded by a mixed inflammatory cell infiltrate with many neutrophils.