25 August 2025
: Case report 
Rapid Progression of Primary Hepatic Neuroendocrine Carcinoma: A Case Report Demonstrating Drastic Oncological Behavior
Challenging differential diagnosis, Diagnostic / therapeutic accidents, Rare disease, Adverse events of drug therapy
Rina Kobayashi BF 1, Tomohide Hori
ABCDEF 1*, Makoto Yamawaki CDF 2, Shigeki Nakayama DF 1, Satoru Umegae DF 1, Takao Iwanaga DF 1, Ryutaro Nishikawa D 1, Takahiro Shimoyama DF 1, Sakurako Suzuki F 1, Shinichiro Atsumi CDF 3, Hiroshi Hasegawa F 2, Shigehito Nakashima DF 2, Kunihiro Higuchi F 2, Kentaro Onishi F 2, Ryotaro Sakaguchi F 2, Shoichi Morita F 2, Haruka Miyao F 2, Saki Aota F 2, Hikaru Ohtani F 1, Takayuki Yamamoto ADF 1
DOI: 10.12659/AJCR.948500
Am J Case Rep 2025; 26:e948500
Figure 8 Enhanced CT findings 67 days after the initial diagnosisNew pulmonary arterial thromboses were observed (A, B, red arrows). The primary hepatic tumor had further enlarged (C–E, yellow arrows), along with metastatic lymph nodes (F, pink and orange arrows). Tumor thromboses had extended into the right and middle HVs (C, D, blue arrows), while PV thrombosis progressed into the left PV and PV trunk (E, F, blue arrows). Additionally, massive ascites (C–F) and new intraperitoneal dissemination (D, green arrow) were detected. CT – computed tomography; HV – hepatic vein; PV – portal vein.