08 January 2026
: Case report 
Diagnostic Challenges in Atypical Hemolytic Uremic Syndrome: A Case of Artificial Mitral Valve Dysfunction as a Possible Trigger for Severe Thrombotic Microangiopathy
Challenging differential diagnosis, Rare disease
Gabriela Kot
ABEF 1, Agata Wróbel ABDEF 1, Błażej Kieszek ABD 2, Zbigniew Sablik ABCE 3, Michał Nowicki ACDEG 2*
DOI: 10.12659/AJCR.948516
Am J Case Rep 2026; 27:e948516
Figure 1 Values of laboratory parameters over time. (A) Hemoglobin concentration (g/dL); (B) platelet concentration (K/μL); (C) serum creatinine concentration (μmol/L); (D) concentration of lactate dehydrogenase (U/L); and (E) international normalized ratio values. Orange dots indicate the administration of eculizumab. Green dots represent the surgical closure of perivalvular mitral valve leakage.