27 August 2025
: Case report 
Extranodal Rosai-Dorfman Disease in a Pediatric Patient: A Case Report
Challenging differential diagnosis, Rare disease
Lili Miles ABCDEF 1*, Caroline Baughn
ABCDEF 2, Gleidson Messias Silva BD 3, Dorothea L. Douglas ABDE 4, Lei Shao BDEF 1
DOI: 10.12659/AJCR.948533
Am J Case Rep 2025; 26:e948533
Figure 1 (A) X-ray of right radius revealed a lytic lesion with a wide zone of transition, cortical destruction (arrows), and poorly defined periosteal reaction. (B) Curettage specimen showed a mixed inflammatory infiltration, including large foamy cells with emperipolesis (H&E, ×40). (C) Most histiocytes stained strongly positive for S-100 (S-100 immunohistochemistry stain, ×40).