28 August 2025
: Case report 
Pancreatic Inflammation Induced by Immune Checkpoint Inhibitors in Melanoma Treatment: A Case Report
Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents, Adverse events of drug therapy
Abdo I. El Tawil ABCDEF 1*, Beatriz A. Mendes ABCDEF 1, Leandro A.F. Machoski ABCDEF 1, Micheli F. Domingos AEF 2, Noelle S. Wassano AEF 3, Sérgio O. Ioshii AEF 4, Eduardo J.B. Ramos AEF 2DOI: 10.12659/AJCR.948580
Am J Case Rep 2025; 26:e948580
Figure 3 Histological section of pancreatic tissue obtained via endoscopic ultrasound-guided biopsy. H&E staining reveals marked acinar atrophy (red arrows) and prominent stromal fibrosis (yellow arrow). There is a significant reduction in exocrine pancreatic parenchyma, replaced by fibrous tissue with scattered inflammatory infiltrates, consistent with chronic pancreatitis. No evidence of neoplastic cells or ductal atypia is observed.