28 August 2025
: Case report 
Pancreatic Inflammation Induced by Immune Checkpoint Inhibitors in Melanoma Treatment: A Case Report
Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents, Adverse events of drug therapy
Abdo I. El Tawil ABCDEF 1*, Beatriz A. Mendes ABCDEF 1, Leandro A.F. Machoski ABCDEF 1, Micheli F. Domingos AEF 2, Noelle S. Wassano AEF 3, Sérgio O. Ioshii AEF 4, Eduardo J.B. Ramos AEF 2DOI: 10.12659/AJCR.948580
Am J Case Rep 2025; 26:e948580
Figure 6 Axial section positron emission tomography-computed tomography (PET-CT) demonstrates the absence of metabolic activity in the pancreatic body, as seen in the last examination (highlighted in yellow), and the development of a discrete area of metabolism in the pancreatic tail (white arrows). This new low-grade hypermetabolic focus was identified without an associated mass effect or anatomical distortion on the corresponding CT images. This was interpreted as physiological or subclinical inflammatory activity. No significant fluorodeoxyglucose uptake is noted in the peripancreatic fat, mesentery, or regional lymph nodes.