26 September 2025
: Case report 
Diagnostic Challenges in Diffuse Large B-Cell Lymphoma in a Young Liver Transplant Patient with Ulcerative Colitis: A Case Report
Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment, Educational Purpose (only if useful for a systematic review or synthesis), Rare coexistence of disease or pathology
Maria Kopoń
ABCDEF 1*, Aleksandra Wileńska AEF 1,2, Marek Zdrenka D 3, Łukasz Szylberg D 3,4, Jarosław Koza ADEF 1,2
DOI: 10.12659/AJCR.948652
Am J Case Rep 2025; 26:e948652
Figure 4 Immunohistochemistry Panel of Diffuse Large B-cell Lymphoma (DLBCL). (A) Hematoxylin and eosin (H&E) staining demonstrates diffuse proliferation of atypical large B-lymphocytes, characterized by irregular nuclear contours and prominent nucleoli. Immunohistochemical analysis (B–M) further characterizes the proliferation: strong expression of CD20 (G) and CD79a (I) confirms B-cell lineage. Absence of CD3 (D) and CD5 (E) expression excludes T-cell lineage. The immunophenotype, positive for CD10 (F) and BCL6 (C) and negative for MUM1 (M) and BCL2 (B), is consistent with a germinal center B-cell-like (GCB) subtype of DLBCL. C-MYC (J) is expressed, while CD30 (H) and Cyclin D1 (K) are negative. A high Ki-67 proliferation index of 98% (L) reflects the aggressive nature of the neoplasm. Original magnification 80×.