Gastric Emptying Delay with Pre-Meal Administration of Metformin and Anagliptin in Type 2 Diabetes: Effects on Postprandial Glucose and Triglyceride Levels in a Two-Case Report

Koichiro Murata; Daisuke Sato; Katsutaro Morino; Shogo Ida; Natsuko Ohashi; Daisuke Takenaka; Natsuko Kitagawa; Mayu Shigemi; Itsuko Miyazawa; Tsuyoshi Yanagimachi; Yukihiro Fujita; Hiroshi Maegawa; Shinji Kume

doi:10.12659/AJCR.948812

15 October 2025 : Case report Japan

Gastric Emptying Delay with Pre-Meal Administration of Metformin and Anagliptin in Type 2 Diabetes: Effects on Postprandial Glucose and Triglyceride Levels in a Two-Case Report

Unusual or unexpected effect of treatment

Koichiro Murata

^{ABCDEFG 1*}, Daisuke Sato^{ABCDEFG 1}, Katsutaro Morino

^{ABCDEFG 1,2}, Shogo Ida^{ABCDEFG 1}, Natsuko Ohashi^{ABCDEFG 1}, Daisuke Takenaka^{BCDEF 1}, Natsuko Kitagawa^{BCDEF 1}, Mayu Shigemi^{BCDEF 1}, Itsuko Miyazawa^{ABCDEFG 1}, Tsuyoshi Yanagimachi^{ABCDEFG 1,3}, Yukihiro Fujita

^{ABCDEFG 1,3}, Hiroshi Maegawa^{ABCDEFG 1,4}, Shinji Kume^{ABCDEFG 1}

DOI: 10.12659/AJCR.948812

Am J Case Rep 2025; 26:e948812

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Figure 2 Effects of pre-meal metformin/anagliptin administration on circulating parameters. Changes in the (A) plasma triglyceride, (B) blood glucose, (C) plasma insulin, and (D) plasma active glucagon-like peptide-1 (GLP-1) concentrations during the meal test.

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Gastric Emptying Delay with Pre-Meal Administration of Metformin and Anagliptin in Type 2 Diabetes: Effects on Postprandial Glucose and Triglyceride Levels in a Two-Case Report

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