30 September 2025
: Case report 
Severe Liver Dysfunction Within 48 Hours of Thionamide Therapy in Thyrotoxicosis: A Case Report
Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment
Christopher Annabi ABCDEF 1, Laila Noor ABCDEF 2, Jamie A. Mullally
ABCDEF 2*
DOI: 10.12659/AJCR.948822
Am J Case Rep 2025; 26:e948822
Figure 1 Liver function test results are shown. (A) Aspartate aminotransferase (AST) levels rapidly decreased after cessation of propylthiouracil on hospital day 3 and gradually returned to normal over the following weeks. (B) Alanine aminotransferase (ALT) levels rapidly decreased after cessation of propylthiouracil on hospital day 3 and gradually returned to normal over the following weeks. (C) Alkaline phosphatase levels decreased following cessation of propylthiouracil on hospital day 3 and then stabilized at a level slightly higher than normal in the following 3 weeks.