11 October 2025
: Case report 
Atraumatic Breast Fat Necrosis Mimicking Malignancy in End-Stage Renal Disease: A Case Report
Unusual clinical course, Challenging differential diagnosis
Victoria Kai Lin Tay
ABCDEFG 1*, Kentson Jing Xin Lee ABCDEFG 2, Lester Chee Hao Leong ABCDEF 3, Sue Zann Lim ABCDE 4,5,6, Inny Busmanis ABCDEFG 7
DOI: 10.12659/AJCR.948834
Am J Case Rep 2025; 26:e948834
Figure 4 (A) Cut sections of the excision biopsy specimen show discrete dark yellow areas (red arrow) interspersed within fibro-fatty parenchyma which felt “gritty” on dissection, an indication of possible fat necrosis. (B) High-power magnification showed circumferential calcifications in blood vessels of varying sizes (blue arrow). On elastic stains (not shown), the calcifications were shown to involve the internal elastic laminae and had a Mönckeberg sclerosis-like pattern. (C) High-power magnification showed extensive fat necrosis. (D) Calcifications in some vessels were so severe that focal vascular occlusion from thrombi formation were seen (black arrow), with accompanying adjacent areas of fat necrosis (asterisk).