Figure 3 Histopathology of invasive ductal carcinoma (IDC) with areolar ulceration: (A) 2× objective (20× total magnification) and (B) 10× objective (100× total magnification) of tumor cells stained with hematoxylin and eosin reveal key cytological features of IDC. An infiltrating carcinoma, primarily located in the dermis of the skin, including the nipple (arrow), was observed. The tumor cells exhibit numerous glandular structures. Pagetoid spread occurs within the epidermis. Ulceration is present in the areola (arrowhead), with exposure to the epidermis. Immunohistochemical staining for (C) estrogen receptor, (D) progesterone receptor, (E) human epidermal growth factor receptor-2 (HER2), and (F) Ki-67 showed that the phenotype of this IDC was hormone receptor-positive and HER2-negative (HR+/HER2−). (C, D): 20× objective (200× total magnification); (E, F): 40× objective (400× total magnification).