15 December 2025
: Case report 
Primary Pulmonary Osteosarcoma Presenting as a 1.7-cm Subpleural Nodule in a 61-Year-Old Man: A Case Report
Unusual clinical course, Challenging differential diagnosis, Rare disease
Xin Yang ABCDEF 1, Wen Guang Zhao BCF 1, Chao Gao ABC 1, Sheng Lin CDF 1,2*DOI: 10.12659/AJCR.949034
Am J Case Rep 2025; 26:e949034
Figure 1 Chest imaging workup of the right upper lobe nodule(A) Computed tomography (CT) from August 2024 shows a 0.7-cm, smooth-edged subpleural nodule. (B) CT from January 2025 demonstrates interval growth to 1.7 cm. (C) Positron-emission tomography/CT reveals increased uptake (SUVmax 5.2). (D) Whole-body bone scintigraphy shows no skeletal uptake, providing evidence against a bone primary or osseous metastasis.