Acute Hemorrhagic Necrotizing Encephalopathy in a COVID-19 Patient With a  Response to Intravenous Immunoglobulin Therapy

Fajer Saleh Almeer; Heba Khalid Alkoheji; Marwa Ebrahim Zayed; Ali Jaffar Al-Hilly; Omar Abduljabar Hussein

doi:10.12659/AJCR.949542

12 February 2026 : Case report Bahrain

Acute Hemorrhagic Necrotizing Encephalopathy in a COVID-19 Patient With a Response to Intravenous Immunoglobulin Therapy

Challenging differential diagnosis, Rare disease

Fajer Saleh Almeer^{ABCDEFG 1*}, Heba Khalid Alkoheji^{ABCDEFG 2}, Marwa Ebrahim Zayed^{ABCDEFG 3}, Ali Jaffar Al-Hilly^{ABCDEFG 3}, Omar Abduljabar Hussein^{ABCDEFG 3}

DOI: 10.12659/AJCR.949542

Am J Case Rep 2026; 27:e949542

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Figure 5 Resolution of thalamic lesions on Follow-up T2-weighted fluid-attenuated inversion recovery sequences (FLAIR) magnetic resonance imaging (MRI)Interval axial T2-weighted FLAIR MRI demonstrates significant reduction in the size and signal intensity of the previously noted bilateral thalamic hyperintense lesions (red arrows) compared to the initial imaging. Interval improvement reflects resolution of the acute inflammatory process in AHNE.

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Acute Hemorrhagic Necrotizing Encephalopathy in a COVID-19 Patient With a Response to Intravenous Immunoglobulin Therapy

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