29 November 2025
: Case report 
Mixed Cryoglobulinemia in the Setting of Monoclonal B-Cell Lymphocytosis and Monoclonal Gammopathy of Unknown Significance: A Case Report
Unknown etiology, Challenging differential diagnosis, Rare coexistence of disease or pathology
Eleni Bouziani
EF 1,2*, Luisa Ladel EF 3,2, Aaron James Stonestrom F 4
DOI: 10.12659/AJCR.949597
Am J Case Rep 2025; 26:e949597
Figure 2 The bone marrow biopsy shows maturing trilineage hematopoiesis with several interstitial lymphoid aggregates, accounting for about 5% of the total marrow cellularity (A). The lymphoid aggregates comprise small lymphocytes with scant cytoplasm, oval nuclei, and condensed chromatin (B). Immunohistochemical study shows a predominance of PAX5-positive B cells within the lymphoid aggregates (C) with fewer CD3-positive B cells (D).