29 November 2025
: Case report 
Mixed Cryoglobulinemia in the Setting of Monoclonal B-Cell Lymphocytosis and Monoclonal Gammopathy of Unknown Significance: A Case Report
Unknown etiology, Challenging differential diagnosis, Rare coexistence of disease or pathology
Eleni Bouziani
EF 1,2*, Luisa Ladel EF 3,2, Aaron James Stonestrom F 4
DOI: 10.12659/AJCR.949597
Am J Case Rep 2025; 26:e949597
Figure 3 Flow cytometric study reveals an abnormal CD5-positive B-cell population with dim CD20 and CD79a, partial CD23, and bimodal CD200 expression (highlighted red population on A). The abnormal B cells show restricted kappa light chain expression. Such immunophenotype supports the diagnosis of chronic lymphocytic leukemia (CLL) or monoclonal B-cell lymphocytosis with CLL phenotype (highlighted green population in B).