29 October 2025
: Case report 
Gastric Adenocarcinoma Resembling Submucosal Tumor: A Case Report
Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment, Rare disease
Hongli Liu ABDE 1, Chao Deng EF 1, Rui Song DE 1, Juan Li BF 1, Song He AE 1, Zhihang Zhou F 1, Suhua Wu F 1, Hongdan Cao E 2, Lin Lv
ADE 1*
DOI: 10.12659/AJCR.949785
Am J Case Rep 2025; 26:e949785
Figure 5 (A) Low-power histologic examination revealed most of the cancer cells are covered with noncancerous epithelium (H&E staining, ×100). (B) High-power histologic examination shows poorly differentiated adenocarcinoma. The tumor consists of large, polygonal, atypical cell nests (H&E staining, ×400). (C) Immunohistochemical staining shows positive expression for cytokeratin (CK), CK7 (partial), CK8/18, caudal-type homeobox 2 (CDX-2) (partial), villin, and Ki-67 (approximately 50%), and negative expression for synaptophysin (Syn), thyroid transcription factor-1 (TTF-1), CD56, CD34, and Epstein-Barr virus in the tumor cells (immunohistochemical staining, ×400).