22 September 2025
: Case report 
Initial Manic Presentation in Creutzfeldt-Jakob Disease: A Case Report
Challenging differential diagnosis, Rare disease, Educational Purpose (only if useful for a systematic review or synthesis)
Fatima Ghazi Alotaibi
ABCDEF 1*, Rakan Bahammam ABCDEF 1, Khalid M. Alqarni ABCDEF 1, Othman O. Aldraihem E 2
DOI: 10.12659/AJCR.949905
Am J Case Rep 2025; 26:e949905
Figure 1 MRI brain showing FLAIR hyperintensity and corresponding diffusion restriction in the bilateral caudate nuclei and putamen, more on the right side, multiple areas of cortical diffusion restriction with mild T2 FLAIR hyperintensity in the bilateral frontal lobes and temporal lobes with involvement of the insular cortex, more on the right side. There is asymmetric bilateral parietal cortical involvement.