23 November 2025
: Case report 
Idiopathic Intracranial Hypertension as the Initial Manifestation of Systemic Lupus Erythematosus: A Case Report and Literature Review
Challenging differential diagnosis, Diagnostic / therapeutic accidents, Management of emergency care, Rare coexistence of disease or pathology
Abdulaziz Almalki AE 1, Asayel Abdullah Alosaimi BEF 2, Abdulhameed Sarriyah
AEFG 2*, Sarah Alqasem AEF 2, Qusai Alwazna AEF 3, Faisal Theeb Alqahtani AEF 2
DOI: 10.12659/AJCR.950115
Am J Case Rep 2025; 26:e950115
Figure 1 Fundoscopic examination using optical coherence tomography (Optic Disc Cube 200×200) revealed bilateral diffuse thickening of the retinal nerve fiber layer (RNFL), increased optic disc volume, and marked elevation in RNFL thickness. These findings are consistent with grade 3–4 papilledema, supporting the clinical suspicion of raised intracranial pressure in this case of idiopathic intracranial hypertension associated with systemic lupus erythematosus.