16 January 2026
: Case report
A 17-Year-Old Male Adolescent With Refractory Crohn’s Disease Managed With Upadacitinib and Risankizumab Combination Therapy: A Case Report and Review of Current Evidence
Unusual or unexpected effect of treatment
Mohammad Alhashemi BCDEF 1, Mohammad ShehabDOI: 10.12659/AJCR.950174
Am J Case Rep 2026; 27:e950174
Figure 2 (A) Biopsy from ascending colon showing moderate active chronic colitis. Active inflammation is seen in the form of crypt abscess (arrow) and neutrophils in lamina propria, while chronic inflammation is seen in the form of crypt architecture distortion and abundant plasma cells in lamina propria (200× magnification). (B) Biopsy from transverse colon showing chronic inflammation in the form of crypt architecture distortion (right) as well as expanded lamina propria by plasma cells, eosinophils, and lymphocytes (left) (100× magnification). (C) Biopsy from transverse colon showing active chronic inflammation. Activity is seen in the form of cryptitis (arrow) (200× magnification). (D) Biopsy from rectum showing chronic inflammation in the form of crypt branching (asterix) and Paneth cell metaplasia (arrow) (150× magnification).






