25 January 2026
: Case report 
Histiocytic Sarcoma Treated With Autologous Stem Cell Transplantation: A Case Report and Literature Review of the Role of Autologous and Allogenic Stem Cell Transplantation
Rare disease
Yun Ji Lee
BCDEF 1, Dong Won Baek AF 1*
DOI: 10.12659/AJCR.950225
Am J Case Rep 2026; 27:e950225
Figure 4 Histopathologic findings of the spleen involved by histiocytic sarcoma. (A) Diffuse infiltration of atypical histiocytic tumor cells replacing the splenic parenchyma (hematoxylin and eosin [H&E] stain; ×100 magnification). (B) The arrow indicates pleomorphic histiocytic cells with abundant eosinophilic, vacuolated cytoplasm and moderate to severe nuclear atypia (H&E stain; ×200 magnification). (C) The arrow shows large tumor cells with erythrophagocytosis (H&E stain; ×400 magnification). (D) Sheets of atypical histiocytic cells admixed with inflammatory cells, showing atypical mitotic figures (H&E stain; ×400 magnification).