31 October 2025
: Case report 
Apical Hypertrophic Cardiomyopathy: Diagnostic Challenges in a Patient with Hypertension and Obstructive Sleep Apnea
Challenging differential diagnosis, Unusual or unexpected effect of treatment, Rare disease, Educational Purpose (only if useful for a systematic review or synthesis)
Jordan Llerena-Velastegui
ACDEF 1,2,3*, Daniela Benitez-Gutierrez ABCD 4, Diego Benitez-Zapata ABCDEF 5, Camila Escobar-Andrade EF 6, Daniela Corral-Hidalgo EF 6
DOI: 10.12659/AJCR.950268
Am J Case Rep 2025; 26:e950268
Figure 1 Electrocardiogram (ECG) interpretation of hallmark repolarization changes in apical hypertrophic cardiomyopathyResting ECG demonstrates sinus rhythm with positive P waves in leads I, II, and aVF, negative in aVR, and biphasic in V1, normal QRS axis at 60°, extensive subepicardial anterolateral ischemic changes, and giant deep T-wave inversions in precordial leads, suggestive of apical hypertrophic cardiomyopathy.