Novel Sequential Therapy with Obinutuzumab and Telitacicept in Severe Lupus Nephritis with Glucocorticoid-Induced Avascular Necrosis (AVN) of the Femoral Head: A Case Report

Yu Zhang; Liqi Huang; Na Li; Xuelin Zeng; Zhihua Zheng; Xiaohua Wang; Yiqing Zhang; Chun Tang

doi:10.12659/AJCR.950362

11 December 2025 : Case report China

Novel Sequential Therapy with Obinutuzumab and Telitacicept in Severe Lupus Nephritis with Glucocorticoid-Induced Avascular Necrosis (AVN) of the Femoral Head: A Case Report

Unusual clinical course

Yu Zhang

^{BCDE 1}, Liqi Huang^{BCDE 1}, Na Li^{BCD 1}, Xuelin Zeng

^{BCF 2}, Zhihua Zheng^{AE 1}, Xiaohua Wang^{AE 1*}, Yiqing Zhang^{ADE 1}, Chun Tang^{ADEF 1}

DOI: 10.12659/AJCR.950362

Am J Case Rep 2025; 26:e950362

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Figure 3 Post-treatment changes in disease activity markers and key indices. (A) Anti-dsDNA antibody level; (B) IgG level; (C) 24-hour urinary protein excretion; (D) SLEDAI score.

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Novel Sequential Therapy with Obinutuzumab and Telitacicept in Severe Lupus Nephritis with Glucocorticoid-Induced Avascular Necrosis (AVN) of the Femoral Head: A Case Report

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