24 December 2025
: Case report 
Conception After Chemotherapy for Intraplacental Choriocarcinoma: Favorable 5-Year Follow-Up of the Mother and Child
Rare disease
Tomoo Suzuki ABCDEF 1, Masanori Ono
CDEF 1*, Junya Kojima BCD 1, Yoshinari Imai B 1, Takeshi Nagai BCD 2, Atsushi Suzuki B 3, Naoaki Kuji BC 1, Hirotaka Nishi ABCDG 1
DOI: 10.12659/AJCR.950426
Am J Case Rep 2025; 26:e950426
Figure 2 Histopathological findings of the placenta from the first pregnancy complicated by intraplacental choriocarcinoma(A) Hematoxylin and eosin (H&E) staining, ×20. The right side of the image shows a broad area of coagulative necrosis. Viable atypical cells proliferated (▲) at the interface with adjacent normal villous tissue (left side). (B) H&E staining, ×200. Atypical trophoblastic proliferation with a mixture of mononucleated cytotrophoblasts (▲) and multinucleated giant trophoblastic cells (syncytiotrophoblasts) (△). (C) Ki-67 immunostaining, ×100. A high proportion of mononuclear tumor cells showed Ki-67 positivity, indicating a high proliferative index. (D) p63 immunostaining, ×100. A subset of mononuclear tumor cells showed nuclear positivity for p63.