30 November 2025
: Case report 
Afebrile HSV-2 Encephalitis with Radiographic Atypia and Minimal Systemic Inflammation: A Case Report
Unusual clinical course, Challenging differential diagnosis
Shunsuke Kondo
ABDEF 1*, Wejdan Abo Qayas EF 2, Osama Hasan EF 1, Rachel Haide N. Tacata E 3, Matthew W. Kobylinski EF 1, Lorrance Majewski E 4
DOI: 10.12659/AJCR.950444
Am J Case Rep 2025; 26:e950444
Figure 1 Brain magnetic resonance imaging with and without contrast. (A) Axial T2/Fluid-Attenuated Inversion Recovery (FLAIR) image shows multifocal cortical and subcortical hyperintensities in the left parieto-occipital region and right parietal cortex. (B) Diffusion-weighted imaging demonstrates trace restricted diffusion in the posterior left parietal lobe. No clinically significant contrast enhancement or mass effect is evident.