30 November 2025
: Case report 
Afebrile HSV-2 Encephalitis with Radiographic Atypia and Minimal Systemic Inflammation: A Case Report
Unusual clinical course, Challenging differential diagnosis
Shunsuke Kondo
ABDEF 1*, Wejdan Abo Qayas EF 2, Osama Hasan EF 1, Rachel Haide N. Tacata E 3, Matthew W. Kobylinski EF 1, Lorrance Majewski E 4
DOI: 10.12659/AJCR.950444
Am J Case Rep 2025; 26:e950444
Figure 2 T2*-Weighted Imaging. Axial T2*-weighted imaging shows punctate hypointense foci in the bilateral parietal lobes, consistent with microhemorrhages (yellow arrows). These findings are unusual in HSV-2 encephalitis and may suggest cortical vascular involvement or more severe local inflammation.