18 November 2025
: Case report 
Primary Cutaneous Cribriform Tumor with Clinical and Histological Diagnostic Challenges: Case Report and Literature Review of a Rare Skin Neoplasm
Challenging differential diagnosis, Rare disease
Wassim Hamadeh
AEF 1*, Elie Berbery AEF 2, Mohammad H. Abbas ABE 1, Racil Allaw ABD 3, Bassam F. Matar AEF 3
DOI: 10.12659/AJCR.950487
Am J Case Rep 2025; 26:e950487
Figure 2 (A, B) Hematoxylin and eosin staining shows solid nests of epithelial cells with oval nuclei and scant eosinophilic cytoplasm. Multiple cribriform areas with small round lumina and thin intraluminal bridging strands are evident (A, scale bar=200 μm; B, scale bar=100 μm). (C) Cytokeratin 7: tumor cells display strong, diffuse cytoplasmic positivity (brown staining) (scale bar=100 μm). No adnexal epithelium was present in this section as an internal control; however, external positive control tissue was used to validate staining. (D) Epithelial membrane antigen (EMA): tumor cells show moderate membranous and cytoplasmic positivity, while non-neoplastic stromal cells act as negative internal controls (scale bar=100 μm).