25 November 2025
: Case report
Full-Thickness Macular Hole After Faricimab Treatment for Branch Retinal Vein Occlusion-Associated Macular Edema with Vitreomacular Traction: A Case Report
Unusual clinical course, Unusual or unexpected effect of treatment
Hiroki SanoDOI: 10.12659/AJCR.950495
Am J Case Rep 2025; 26:e950495
Figure 1 Clinical course from presentation to FTMH formation.(A) Horizontal OCT scan obtained at the referring eye clinic, showing focal VMT with an LMH but no macular edema. (B) Vertical OCT scan from the referring clinic confirming focal VMT and LMH. (C) Initial fundus photograph showing superonasal BRVO with intraretinal hemorrhage. (D) Horizontal OCT scan at presentation showing CME with VMT, an ERM, and an LMH. (E) Vertical OCT scan at presentation showing similar findings, with a vertical hyperreflective line at the fovea (white arrow), indicative of early biomechanical stress. (F) Fundus photograph obtained 1 week after intravitreal faricimab injection, showing reduction of intraretinal hemorrhage. (G) Horizontal OCT scan at 1 week showing improvement in macular edema with persistent VMT. (H) Vertical OCT scan at 1 week consistent with findings in (E). (I) Fundus photograph at 1 month showing further resolution of hemorrhage. (J) Horizontal OCT scan at 1 month showing formation of a stage 2 FTMH at the site of the prior vertical hyperreflective line (white arrowhead). (K) Vertical OCT scan at 1 month confirming the macular hole. BRVO – branch retinal vein occlusion; CME – cystoid macular edema; ERM – epiretinal membrane; FTMH – full-thickness macular hole; LMH – lamellar macular hole; OCT – optical coherence tomography; VMT – vitreomacular traction.






