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25 November 2025 : Case report  Japan

Full-Thickness Macular Hole After Faricimab Treatment for Branch Retinal Vein Occlusion-Associated Macular Edema with Vitreomacular Traction: A Case Report

Unusual clinical course, Unusual or unexpected effect of treatment

Hiroki Sano ORCID logo ABDEF 1*, Ryoji Yanai ORCID logo ADEF 2, Yoshinori Mitamura ADEF 2

DOI: 10.12659/AJCR.950495

Am J Case Rep 2025; 26:e950495

Figure 4 Changes following recurrence of macular edema and response to additional faricimab injection.(A) Fundus photograph at 6 weeks postoperatively showing further reduction of intraretinal hemorrhage. (B) Horizontal OCT scan at 6 weeks postoperatively showing increased retinal thickening and cystoid changes, indicating worsening macular edema. (C) Vertical OCT scan at 6 weeks postoperatively showing persistent FTMH closure with prominent cystoid spaces, particularly in the superior parafoveal region. (D) OCT thickness map at 6 weeks postoperatively showing pronounced thickening in the superior parafoveal region, consistent with edema exacerbation. (E) ETDRS 9-sector grid at 6 weeks postoperatively showing increased thickness in the central and superior subfields. (F) Fundus photograph at 7 weeks postoperatively (1 week after additional intravitreal faricimab injection) showing a stable retinal appearance. (G) Horizontal OCT scan at 7 weeks postoperatively showing substantial reduction of macular edema. (H) Vertical OCT scan at 7 weeks postoperatively confirming resolution of cystoid spaces and sustained FTMH closure. (I) OCT thickness map at 7 weeks postoperatively showing substantial reduction of retinal thickness across all subfields. (J) ETDRS 9-sector grid at 7 weeks postoperatively confirming normalization of thickness in the central and superior subfields. ETDRS – Early Treatment Diabetic Retinopathy Study; FTMH – full-thickness macular hole; OCT – optical coherence tomography.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923