06 November 2025
: Case report 
A Rare Diagnosis of HPV-Positive Rectal Squamous Cell Carcinoma in a 59-Year-Old Heterosexual Woman: Implications for Screening Guidelines
Rare disease, Educational Purpose (only if useful for a systematic review or synthesis), Rare coexistence of disease or pathology
Adebola O. Adetiloye
BDEF 1*, Anim Asif BEF 1, Olurotimi J. Badero EF 2, Zimri Tan E 1, Earl Scott E 1
DOI: 10.12659/AJCR.950554
Am J Case Rep 2025; 26:e950554
Figure 2 Hematoxylin and eosin–stained histopathology slide of rectal squamous cell carcinoma. (A) High-power view showing nests of malignant squamous cells with pleomorphic nuclei, prominent nucleoli, and an increased nuclear-to-cytoplasmic ratio (blue arrow). (B) Low-power view demonstrating larger infiltrating tumor nests. These findings are consistent with a moderately differentiated, non-keratinizing squamous cell carcinoma.