04 May 2026
: Case report 
Extensive Temporal Bone Necrosis in Petrous Bone Cholesteatoma Complicated by Actinomycosis: A Case Report
Challenging differential diagnosis, Unusual or unexpected effect of treatment, Educational Purpose (only if useful for a systematic review or synthesis), Rare coexistence of disease or pathology
Saverio Nicoletti ABEF 1*, Giannicola Iannella AF 1, Giuseppe Magliulo BD 1, Daniela Messineo
B 2, Alessandro Corsi B 3, Annalisa Pace CE 1
DOI: 10.12659/AJCR.950701
Am J Case Rep 2026; 27:e950701
Figure 3 Histological view of the cholesteatoma is shown in (A). Panel (B) illustrates the necrotic bone associated with acute inflammation, keratinous debris and colonies of Actinomyces spp. Panel (C) illustrates the extensive scalloping of the bone surface. Colonies of Actinomyces spp, inflammatory cells, in which neutrophil granulocytes are predominant, and keratinous debris (arrow) are highlighted in panel (D) Colonies of Actinomyces are identified by asterisks in panels B–D. (A–D) Hematoxylin-eosin. Bars: 500 microns in A and B and 200 microns in C and D.