24 April 2026
: Case report 
A 68-Year-Old Man With Neutrophil-Rich Hepatoid Adenocarcinoma of the Gallbladder
Challenging differential diagnosis, Rare coexistence of disease or pathology
Mingxia Chen
ABCDEF 1*, Fanhong Kong BCEF 1, Min Wang BC 1, Yuanyuan Li B 1, Baojuan Gao D 2
DOI: 10.12659/AJCR.950825
Am J Case Rep 2026; 27:e950825
Figure 3 Histological features of hepatoid adenocarcinoma of the gallbladder with neutrophilic infiltration(asterisk): (A) Hepatoid differentiation: Large, polygonal tumor cells exhibiting eosinophilic granular cytoplasm, round or oval nuclei (hematoxylin and eosin [H&E], 400×). (B) Signet ring cells observed in some areas of the tumor (arrows) (H&E 400×). (C) The foci of high-grade dysplasia/carcinoma in situ (arrows) (H&E 400×). (D) Metastatic lesions in the omentum (arrows), admixed with remarkable neutrophilic infiltration (H&E 20×, higher magnification, H&E 400×).