Logo American Journal of Case Reports

Call: 1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo American Journal of Case Reports Logo American Journal of Case Reports Logo American Journal of Case Reports

21 March 2026 : Case report  Japan

Janus Kinase Inhibitor Upadacitinib in Elderly-Onset Rheumatoid Arthritis With Hip Osteoarthritis: A Case Report

Unusual or unexpected effect of treatment, Patient complains / malpractice, Unexpected drug reaction, Clinical situation which can not be reproduced for ethical reasons, Rare coexistence of disease or pathology

Yusuke Sanji ABCDEFG 1*, Isao Matsushita ADE 2, Eiji Takahashi A 1, Makoto Fukui A 1, Hironori Kitajima ORCID logo A 1, Ayumi Kaneuji A 1

DOI: 10.12659/AJCR.950915

Am J Case Rep 2026; 27:e950915

Figure 2 Anteroposterior radiographs of hips(A) Baseline radiographs at the initial visit; (B) 4 months after initiating rheumatoid arthritis (RA) treatment at our institution; (C) 8 months (2 months after initiation of upadacitinib [UPA]); and (D) 12 months (6 months after initiation of UPA). At baseline (A), the right hip shows a reduced center-edge angle of approximately 15°, complete loss of the joint space predominantly in the weight bearing region with circumferential narrowing, and marked subchondral sclerosis around the superior acetabulum, consistent with end-stage osteoarthritis (OA). Osteophyte formation is only mild; together with the circumferential joint space loss, these findings suggest concomitant degenerative OA and inflammatory arthropathy related to RA. In contrast, the left hip appears largely preserved, highlighting the marked deformity of the right hip. Subchondral bone changes became more apparent over time, particularly after initiation of UPA. Figures a–d show the corresponding magnified images for each time point.

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923