27 February 2026
: Case report 
Management of Extensive Xanthogranulomatous Cholecystitis Lesions: A Case Report
Unusual clinical course, Challenging differential diagnosis
Junzong Chen BCDEF 1, Yanhong Gao BF 2, Di Tang
ACEG 1,3*
DOI: 10.12659/AJCR.951051
Am J Case Rep 2026; 27:e951051
Figure 4 Resected gallbladder specimen and histopathological examination with HE staining. (A) Gross specimen showing multiple black stones (approximately 5 mm in diameter) within the gallbladder, yellowish, turbid, pus-like fluid, and yellow granulation tissue (approximately 5×3 cm) at the gallbladder base (yellow circle). (B) Histopathology revealing significant fibrous tissue hyperplasia, hyaline degeneration, and dense infiltration of histiocytes, foam cells (black arrow), inflammatory cells (red arrow) in the gallbladder wall, consistent with XGC and abscess formation.