16 March 2026
: Case report 
A 53-Year-Old Male Smoker With Advanced Oral Squamous Cell Carcinoma Associated With Paraneoplastic Leukemoid Reaction
Challenging differential diagnosis, Unusual setting of medical care, Rare coexistence of disease or pathology
Chi-Yuan Yeh
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DOI: 10.12659/AJCR.951056
Am J Case Rep 2026; 27:e951056
Figure 2 Microscopically, the sections showed a picture of well-differentiated squamous cell carcinoma, with epidermoid tumor cells showing enlarged hyperchromatic nuclei, abundant eosinophilic cytoplasm and keratin formation and occasional mitosis. The surrounding stroma exhibits desmoplastic fibrosis. (A) Immunohistochemistry hematoxylin and eosin stain at 200× shows well-differentiated squamous cell carcinoma with increased keratinization (black arrow). (B) Negative p16 stain at 200× excludes human papilloma virus–related oral squamous cell carcinoma.